I for myself try to play "real" chords as much as possible, and even when I play power chords, I've started adding the rest of my fingers to get a full six string major or minor chord. Maybe it's because I write my songs on my acoustic guitar primarily. Power chords are ok, but real chords sound more like garage punk, I think. Real chords somehow feel not as solid as a wall, but rather delicate, richer, but also thinner in power (that's why they're no power chords), so it's not so much "rock" but more "garage", if you know what I mean.
Another pro for real chords in my opinion is that when you've learned and practiced them a bit, you don't need to climb up and down your fretboard but can keep your hand at one position, which is much more comfortable for lazy ol' me. And with the variations on the chords you can fake guitar solos without knowing how to play guitar solos...